QUiCKR Case Studies
Focus on your results, run QC workflows seamlessly

See how leading cell & gene therapy teams implement QUiCKR to cut turnaround times, reduce genomics spend, and accelerate their path to IND.

Case study 01 · Editing QC

Cutting potency analysis from 5 days to 20 minutes

A leading Boston Biotech needed to screen 24 LNP dosages to determine editing efficiency across multiple nuclease conditions. NGS turnaround was the rate-limiting step — consuming 70% of their QC budget and slowing iteration to once per week. With QUiCKR this team was able to 5x the throughput/week and reduce their spend by 75%.

Comparison
Amplicon Sequencing Workflow (Before)
Turnaround time
 
5 days
Samples/week
 
200
Cost/Sample
 
$40
QUiCKR Editing QC (After)
Turnaround time
 
1 hour
Samples/week
 
1,000
Cost/Sample
 
$10
QUiCKR workflow — Editing QC
1
Prepare Amplicon
User prepared
2
Serial dilution in QUiCKR buffer
5 min
3
Transfer to QUiCKR Plate
5 min
4
Fluorescence kinetic read at 37°C
10 min — qPCR Machine or Plate Reader
5
ML-based cloud analysis, instant results
0 min — automated
120×
Faster results vs NGS turnaround
70%
Reduction in genomics spend
R² = 0.97
with Amp-Seq
"The queue used to be a constant bottleneck for our upstream teams. Since switching to QUiCKR, sample volume has tripled and researchers finally have a system that keeps pace with their experiments." — Senior scientist, NGS Core (Boston Gene Editing Leader)
Case study 02 · Vector QC

AAV titer QC in 1 hour for process development scale-up

A Gene Therapy CDMO running AAV manufacturing for multiple client programs needed rapid in-process controls. Their ddPCR workflow required 8 hours and specialized operators. QUiCKR Vector QC gave them same-hour QC decisions and 5x more throughput — without adding instruments or headcount.

Comparison
ddPCR Workflow (Before)
Time to result
 
8 hrs
Hands-on time
 
90 min
Samples/run
 
20
QUiCKR Vector QC (After)
Time to result
 
1 hour
Hands-on time
 
20 min
Samples/run
 
100
QUiCKR workflow — Vector QC
1
DNase + PK-Treatment
40 min
2
Serial dilution in QUiCKR buffer
5 min
3
Transfer to pre-plated 384-well reagents
5 min
4
Fluorescence kinetic read at 37°C
10 min — qPCR Machine or Plate Reader
5
ML-based cloud analysis, instant results
0 min — automated
72×
Reduction in hands-on time per plate
8×
Faster results vs ddPCR
R² = 0.94
with ddPCR
"QUiCKR allows us to QC all steps same-day, from Post-lysis and Post-DF to Post-IDX and Purified." — Process development lead, gene therapy CDMO
Case study 03 · Genome Integrity

Catching genomic abnormalities at every iPSC passage — before they compound

A clinical-stage cell therapy company manufacturing iPSC-derived products needed to monitor chromosomal integrity at each passage during process development. Traditional karyotyping took 10 days per lot, meaning abnormalities were often detected only after multiple downstream passages — too late to course-correct without significant rework.

Comparison
NGS Karyotyping (Before)
Time per passage check
 
10 days
Cost/Sample
 
$2000
Passages monitored
 
Selected only
QUiCKR Genome Integrity (After)
Time per passage check
 
80 min
Cost/Sample
 
$200
Passages monitored
 
Every passage
QUiCKR workflow — Genome Integrity
1
Multiplexed PCR
60 min — QuickExtract then QUiCKR optimized PCR
2
Serial dilutions in QUiCKR buffer
5 min
3
Transfer to pre-plated 384-well reagents
5 min
4
Fluorescence kinetic read at 37°C
10 min — qPCR Machine or Plate Reader
5
Cloud-based ML quantification
0 min — instant results
20×
Faster than karyotyping per passage
100%
Of passages monitored — not just selected lots
90%
Cost reduction
"Passage abnormality insights were limited by our analytical bottlenecks. By the time karyotyping flagged a chromosomal abnormality, the cell lines had already expanded multiple times. QUiCKR lets us catch issues at the passage they appear — not weeks later." — Process Development Scientist, clinical-stage iPSC cell therapy company

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