From target to IND 1 year faster

Learn how QUiCKR speeds your time to market across Discovery, Lead Optimization and Process Development

Discovery

Lead Optimization

Process Development

Discovery

Nuclease Optimization

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QUiCKR Applications

QUiCKR saves months per project and 50% of cell culture waste

Discovery

Lead Optimization

Process Development

Nuclease Optimization

Expanded Target Sites

Repair Mechanism

Temporal and Spatial Control of Editing

Minimize adverse immune reactions

QUiCKR Value Add

Accelerates nuclease optimization by saving weeks on each iteration, and months across the entire program
Reduces the number of total variants to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer variants.
Reduces NGS costs and queue
Provides flexibility and control of timeline by enabling teams to generate their own data without cross-team coordination

Cell-Line Generation

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QUiCKR Applications

QUiCKR saves months per project and 50% of cell culture waste

Discovery

Lead Optimization

Process Development

Cell-Line Generation

Real-time QC

Genome Integrity

QUiCKR Value Add

Same day QC and ranking of bulk edited populations, informing the subcloning process
Eliminates wasted cell culture by selecting the optimal cells instantly
Simplifies cell line routine testing of purity and de novo mutations.
Real-time data generation for time point collections, without the need to predict for how long to collect samples for a bulk submission
Reduces NGS costs and queue, and gives clarity on which samples to prioritize for in-depth bioinformatic analysis

Lead Optimization

gRNA Optimization

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QUiCKR Applications

QUiCKR speeds-up iterations by 5X, reduces NGS cost and queue

Discovery

Lead Optimization

Process Development

gRNA Optimization

Protospacer Length

5′ End Modifications

Cas Scaffold Engineering

QUiCKR Value Add

Accelerates gRNA optimization by saving weeks on each iteration, and months for the total program
Reduces the number of designs to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer designs.
Reduces NGS costs and queue

Delivery Optimization

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QUiCKR Applications

QUiCKR speeds-up iterations by 5X, reduces NGS cost and queue

Discovery

Lead Optimization

Process Development

Delivery Optimization

LNP Composition, AAV Optimization

Cargo Ratio, Dose Optimization

Electroporation Parameters Optimization

QUiCKR Value Add

Accelerates delivery optimization by saving weeks on each iteration, and months for the total program
Reduces the number of designs to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer designs.
Reduces NGS costs and queue.

Animal Studies

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QUiCKR Applications

QUiCKR speeds-up iterations by 5X, reduces NGS cost and queue

Discovery

Lead Optimization

Process Development

Animal Studies

Editing Temporal Tracking

Dose Dependent Editing

Biodistribution Studies

QUiCKR Value Add

Accelerates tissue and dose optimization by saving weeks at each iteration.
Reduces the number of variations to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer variations.
Fast turnaround enables same day decisions on prioritization of time sensitive samples to be used for complex functional characterization
Reduces NGS costs and queue

Process Development

Manufacturing

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QUiCKR Applications

QUiCKR enables point-of-need control of timely results for PD

Discovery

Lead Optimization

Process Development

Manufacturing

Editor efficacy QC

Cell isolation/expansion QC

QUiCKR Value Add

Enable rapid go/no go decisions on manufactured batches
Provides flexibility and control of timely results by enabling point-of-need generation of data without cross-team coordination
Reduces NGS costs and queue

In-Process Controls

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QUiCKR Applications

QUiCKR enables point-of-need control of timely results for PD

Discovery

Lead Optimization

Process Development

In-Process Controls

Delivery efficacy QC

Batch Release QC

QUiCKR Value Add

Same day QC and ranking of bulk edited populations, informing the subcloning process
Eliminates wasted cell culture by selecting the optimal cells instantly
Real-time data generation for time point collections, without the need to predict for how long to collect samples for a bulk submission
Reduces NGS costs and queue, and gives clarity on which samples to prioritize for in-depth bioinformatic analysis