Customer Success

QC that keeps up
with your science

See how leading gene therapy teams use QUiCKR to cut turnaround times, reduce NGS spend, and accelerate their path to IND.

Editing QC Vector QC Genome Integrity Academic Research Biotech CDMO
Case Study 01 · Editing QC

Cutting gRNA screening time
from 5 days to 20 minutes

A Stanford-affiliated gene therapy lab needed to screen 48 gRNA candidates per week across multiple nuclease conditions. NGS turnaround was the rate-limiting step — consuming 70% of their QC budget and slowing iteration to once per week.

⚠ Before QUiCKR
Turnaround time5 days
Samples / week48
NGS cost / plate~$2,400
✓ After QUiCKR
Turnaround time20 min
Samples / week1,500+
NGS cost / plate~$680
QUiCKR Workflow — Editing QC
1
Extract genomic DNA or amplicon
0 min — user prepared
2
Serial dilution in QUiCKR buffer
5 min
3
Transfer to pre-plated 384-well reagents
5 min
4
Fluorescence kinetic read at 37°C
10 min — plate reader
5
ML-based cloud analysis, instant results
0 min — automated
120×
Faster results vs NGS turnaround
70%
Reduction in genomics spend
More iteration cycles per month

"We went from waiting a week for NGS results to having indel quantification in hand before lunch. It completely changed how we prioritize gRNA candidates."

— Research Scientist, gene therapy program (Stanford-affiliated lab)
Case Study 02 · Vector QC

AAV titer QC in 1 hour for
process development scale-up

A biotech CDMO running AAV manufacturing for multiple client programs needed rapid in-process controls. Their ddPCR workflow required 4–6 hours and specialized operators. QUiCKR Vector QC gave them same-day QC decisions — without adding instruments or headcount.

⚠ ddPCR Workflow (Before)
Time to result4–6 hrs
Hands-on time~90 min
Samples / run~20
✓ QUiCKR Vector QC (After)
Time to result1 hour
Hands-on time~20 min
Samples / run150
Automation Partners Validated
Opentrons Flex
Hamilton STAR
Beckman Biomek i7
Eppendorf EpMotion
72×
Reduction in hands-on time per plate
1 hr
AAV sample to result vs 4–6 hrs
150
Samples per plate, 384-well format

"We run three client programs in parallel. QUiCKR let us close the QC loop the same day we manufacture. That kind of feedback loop was impossible with ddPCR."

— Process Development Lead, gene therapy CDMO
Case Study 03 · Genome Integrity

Catching genomic abnormalities at every
iPSC passage — before they compound

A clinical-stage cell therapy company manufacturing iPSC-derived products needed to monitor chromosomal integrity at each passage during process development. Traditional NGS-based karyotyping took 2–3 weeks per lot, meaning abnormalities were often detected only after multiple downstream passages — too late to course-correct without significant rework.

⚠ NGS Karyotyping (Before)
Time per passage check2–3 weeks
Cost per lot~$6,000–$8,000
Passages monitoredSelected lots only
Turnaround vs manufacturingLagging by weeks
✓ QUiCKR Genome Integrity (After)
Time per passage check80 min
Cost per lot~$1,800–$2,400
Passages monitoredEvery passage
Turnaround vs manufacturingSame day
QUiCKR Workflow — Genome Integrity
1
Multiplexed PCR with QuickExtract
0 min — QuickExtract then QUiCKR optimised PCR
2
Serial dilutions in QUiCKR buffer
60 min
3
Transfer to pre-plated 384-well reagents
65 min
4
Fluorescence kinetic read at 37°C
70 min — plate reader
5
Cloud-based ML quantification
80 min — instant results
What QUiCKR Detects
Chromosomal copy number variations (CNVs)
Loss of heterozygosity (LOH) events
Off-target genomic alterations from editing
Allele dropout across passages
20×
Faster than NGS karyotyping per passage
100%
Of passages monitored — not just selected lots
70%
Cost reduction vs NGS per passage check

"We were flying blind between passages. By the time NGS flagged a chromosomal abnormality, we'd already expanded that line three more times. QUiCKR lets us catch issues at the passage they appear — not weeks later."

— Process Development Scientist, clinical-stage iPSC cell therapy company

Ready to run QC in minutes,
not weeks?

Book a 30-minute virtual demo. We'll walk through your specific use case and show you what QUiCKR V2 can do for your program.

Book a Demo Download Data Sheet
Customer success

QC that keeps up with your science

See how leading gene therapy teams use QUiCKR to cut turnaround times, reduce NGS spend, and accelerate their path to IND.

Editing QCVector QCGenome integrityAcademic researchBiotechCDMO

Cutting gRNA screening time from 5 days to 20 minutes

A Stanford-affiliated gene therapy lab needed to screen 48 gRNA candidates per week across multiple nuclease conditions. NGS turnaround was the rate-limiting step — consuming 70% of their QC budget and slowing iteration to once per week.

Before QUiCKR

Turnaround time

5 days

Samples/week

48

NGS cost/plate

~$2,400

After QUiCKR

Turnaround time

20 min

Samples/week

1,500+

NGS cost/plate

~$680

QUiCKR workflow — editing QC
1
Extract genomic DNA or amplicon
0 min — user prepared
2
Serial dilution in QUiCKR buffer
5 min
3
Transfer to pre-plated 384-well reagents
5 min
4
Fluorescence kinetic read at 37°C
10 min — plate reader
5
ML-based cloud analysis, instant results
0 min — automated
120×
Faster results vs NGS turnaround
70%
Reduction in genomics spend
More iteration cycles per month

“We went from waiting a week for NGS results to having indel quantification in hand before lunch. It completely changed how we prioritize gRNA candidates.”

— Research scientist, gene therapy program (Stanford-affiliated lab)

AAV titer QC in 1 hour for process development scale-up

A biotech CDMO running AAV manufacturing for multiple client programs needed rapid in-process controls. Their ddPCR workflow required 4–6 hours and specialized operators. QUiCKR Vector QC gave them same-day QC decisions — without adding instruments or headcount.

ddPCR workflow (before)

Time to result

4–6 hrs

Hands-on time

~90 min

Samples/run

~20

QUiCKR Vector QC (after)

Time to result

1 hour

Hands-on time

~20 min

Samples/run

150

Automation partners validated
Opentrons Flex
Hamilton STAR
Beckman Biomek i7
Eppendorf EpMotion
72×
Reduction in hands-on time per plate
1 hr
AAV sample to result (vs 4–6 hrs)
150
Samples per plate, 384-well format
0
New instruments required

“We run three client programs in parallel. QUiCKR let us close the QC loop the same day we manufacture. That kind of feedback loop was impossible with ddPCR.”

— Process development lead, gene therapy CDMO

Detecting off-target edits before IND — without the wait

A clinical-stage gene therapy company needed to demonstrate genome stability and detect potential off-target integrations as part of their IND package. Traditional NGS-based genome integrity testing took 3–4 weeks per lot. QUiCKR’s CRISPR kinetics-based platform enabled the same detection with same-day results.

Legacy NGS (before)

Time per lot

3–4 wks

Cost per lot

~$8,000

Off-target sensitivity

~0.1%

QUiCKR genome integrity (after)

Time per lot

Same day

Cost per lot

~$2,400

Off-target sensitivity

Amp-Seq

What QUiCKR detects

Indels (insertions / deletions)

HDR knock-in efficiency

Single nucleotide polymorphisms (SNPs)

Off-target genomic alterations

Allele frequency across cell populations

70%
Cost reduction vs NGS per lot
<1 day
Turnaround (vs 3–4 weeks)
IND-ready
Amp-Seq level accuracy, regulatory-compatible

“Our IND timeline moved up by 6 months. We could iterate on our cell manufacturing process in real time rather than waiting weeks to know if a lot passed QC.”

— VP of process development, clinical-stage gene therapy company

Get started

Ready to run QC in minutes, not weeks?

Book a 30-minute virtual demo. We’ll walk through your specific use case and show you what QUiCKR V2 can do for your program.

Book a demoDownload data sheet