From target to IND 1 year faster
Learn how QUiCKR speeds your time to market across Discovery, Lead Optimization and Process Development
Discovery
Lead Optimization
Process Development
Discovery
Nuclease Optimization
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QUiCKR Applications
QUiCKR saves months per project and 50% of cell culture waste
Discovery
Lead Optimization
Process Development
Nuclease Optimization
Expanded Target Sites
Repair Mechanism
Temporal and Spatial Control of Editing
Minimize adverse immune reactions
QUiCKR Value Add
- Accelerates nuclease optimization by saving weeks on each iteration, and months across the entire program
- Reduces the number of total variants to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer variants.
- Reduces NGS costs and queue
- Provides flexibility and control of timeline by enabling teams to generate their own data without cross-team coordination
Capsid Optimization
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QUiCKR Applications
QUiCKR saves 2 days on each QC run
Discovery
Lead Optimization
Process Development
Capsid Optimization
Viral Titer
Structural Variant Quantification
QUiCKR Value Add
- Same hour QC of manufacturing performances
- Real-time routine monitoring
- Eliminates late troubleshooting
- Simple and automated workflow
Cell-Line Generation
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QUiCKR Applications
QUiCKR saves months per project and 50% of cell culture waste
Discovery
Lead Optimization
Process Development
Cell-Line Generation
Real-time QC
Genome Integrity
QUiCKR Value Add
- Same day QC and ranking of bulk edited populations, informing the subcloning process
- Eliminates wasted cell culture by selecting the optimal cells instantly
- Simplifies cell line routine testing of purity and de novo mutations.
- Real-time data generation for time point collections, without the need to predict for how long to collect samples for a bulk submission
- Reduces NGS costs and queue, and gives clarity on which samples to prioritize for in-depth bioinformatic analysis
Lead Optimization
gRNA Optimization
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QUiCKR Applications
QUiCKR speeds-up iterations by 5X, reduces NGS cost and queue
Discovery
Lead Optimization
Process Development
gRNA Optimization
Protospacer Length
5′ End Modifications
Cas Scaffold Engineering
QUiCKR Value Add
- Accelerates gRNA optimization by saving weeks on each iteration, and months for the total program
- Reduces the number of designs to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer designs.
- Reduces NGS costs and queue
Delivery Optimization
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QUiCKR Applications
QUiCKR speeds-up iterations by 5X, reduces NGS cost and queue
Discovery
Lead Optimization
Process Development
Delivery Optimization
LNP Composition, AAV Optimization
Cargo Ratio, Dose Optimization
Electroporation Parameters Optimization
QUiCKR Value Add
- Accelerates delivery optimization by saving weeks on each iteration, and months for the total program
- Reduces the number of designs to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer designs.
- Reduces NGS costs and queue.
Animal Studies
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QUiCKR Applications
QUiCKR speeds-up iterations by 5X, reduces NGS cost and queue
Discovery
Lead Optimization
Process Development
Animal Studies
Editing Temporal Tracking
Dose Dependent Editing
Biodistribution Studies
QUiCKR Value Add
- Accelerates tissue and dose optimization by saving weeks at each iteration.
- Reduces the number of variations to screen. QUiCKR enables fast feedback loops for real-time-informed iterations on fewer variations.
- Fast turnaround enables same day decisions on prioritization of time sensitive samples to be used for complex functional characterization
- Reduces NGS costs and queue
Process Development
Manufacturing
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QUiCKR Applications
QUiCKR enables point-of-need control of timely results for PD
Discovery
Lead Optimization
Process Development
Manufacturing
Editor efficacy QC
Cell isolation/expansion QC
QUiCKR Value Add
- Enable rapid go/no go decisions on manufactured batches
- Provides flexibility and control of timely results by enabling point-of-need generation of data without cross-team coordination
- Reduces NGS costs and queue
In-Process Controls
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QUiCKR Applications
QUiCKR enables point-of-need control of timely results for PD
Discovery
Lead Optimization
Process Development
In-Process Controls
Delivery efficacy QC
Batch Release QC
QUiCKR Value Add
- Same day QC and ranking of bulk edited populations, informing the subcloning process
- Eliminates wasted cell culture by selecting the optimal cells instantly
- Real-time data generation for time point collections, without the need to predict for how long to collect samples for a bulk submission
- Reduces NGS costs and queue, and gives clarity on which samples to prioritize for in-depth bioinformatic analysis
Automation Partners
Opentrons Flex App Note
Revvity Fontus App Note (released soon)
Eppendorf EpMotion App Note (released soon)
Hamilton STAR App Note (released soon)
Biomek i7 App Note (released soon)